Clinical Reference — Physician Use Only. Evidence ratings (1–10) reflect quality of human data: 1–3 = animal/in vitro only, 4–5 = small human studies or case series, 6–7 = multiple human trials, 8–9 = RCTs/FDA approval, 10 = multiple Phase III RCTs. Evidence quality does not equal clinical utility. Regulatory status reflects April 2026 — pending formal FDA publication. All prescribing requires clinical judgment, informed consent, and appropriate monitoring.